The study, published July 6 in Science, used CRISPR Targeting to target extra chromosomes, known as aneuploidy, in melanoma, gastric cancer and ovarian cell lines. Researchers removed a long portion of chromosome 1, which is found in several cancers and linked to disease progression.
The study found aneuploidies play a role in cancer development and eliminating them stunts growth potential. Aneuploidy also causes “collateral therapeutic vulnerabilities that can be targeted to selectively eliminate cells with chromosome dosage imbalances,” researchers wrote.
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